Experimentation and computation work together in our cohesive platform to span chemistry, biology, and the clinic. We uniquely illuminate how molecules impact cellular functions at scale and how these translate into patient biology. Transcripta Bio is not just a first-of-its-kind company, it’s a new kind of drug discovery.
Our platform integrates cutting-edge lab technology with AI trained on fit-for-purpose screening data to let us link chemical structure directly to cellular behavior, accelerating discovery and addressing diseases as systems.
We screen drugs in high-fidelity human cell lines designed in-house to represent healthy and diseased tissues. Our high-throughput, industrialized screening process measures the full-transcriptome drug response, allowing us to map every gene affected by every molecule we screen. We have systematically screened a diverse library of molecules covering the full druggable target space, enabling us to query and predict rich cellular responses in silico and at scale.
Measuring gene expression across multiple dimensions — including multiple concentrations, time after treatment, cell types and cocultures — reveals cellular responses in higher resolution than ever before. Our proprietary computational methods leverage the dynamics across these dimensions to precisely characterize the multiscale cellular behavior over genes, pathways, and cellular functions.
Our machine learning platform built on our proprietary dataset predicts novel molecules that modulate genes and pathways of interest in desired directions. The high-resolution of our screening data is critical for accurate gene response prediction. In our lab, we routinely synthesize and validate virtual screen candidates selected from billions-scale chemical spaces by our models.
Using our rich characterization of cellular function and drug response, along with our lab platform, we can quickly design validation experiments in disease-specific models to prove the therapeutic potential of drug candidates. In our clinical-stage programs, we observe that the same cellular behaviors visible in our lab data replicate in gene expression measurements of treated patients, enabling rapid biomarker development to inform trial qualification and monitoring.
Transcripta Bio bridges structural and systems biology to discover new drugs. Our lab platform captures detailed cellular responses to drug molecules and enables our AI-guided computational platform to directly predict new chemical structures that modulate cellular function. This concerted integration of structure and system is what creates a truly new kind of drug discovery.
To help humanity through impactful innovation.